Fuente: WIPO "tomato" The invention provides methods of treatment of a neurodegenerative disease in a subject, which methods comprise orally administering to said subject a methylthioninium (MT) containing compound, wherein said administration is at a dosage frequency of less than once daily; and wherein said administration provides an amount of MT to the subject that corresponds to an average of between 0.05 mg and 30 mg MT per day, preferably between 0.1 mg and 20 mg MT per day. The invention further provides related compositions and kits of parts for use in the method.