Fuente: WIPO "tomato" Compositions and methods for binding to a target sequence of interest are provided. The compositions find use in editing a target sequence of interest via polymerase editing. Compositions comprise: reverse transcriptases (RTs) (and polynucleotides encoding the same); DNA-binding polypeptides (and polynucleotides encoding the same); polymerase editor (PE)-enhancing polypeptides (and polynucleotides encoding the same); fusion proteins comprising an RT and a heterologous polypeptide, where the heterologous polypeptide can include a DNA-binding polypeptide and a PE-enhancing polypeptide; polymerase editors (PEs) comprising an RT and a DNA-binding polypeptide, optionally further including a PE-enhancing polypeptide (or one or more polynucleotides encoding any or all components of the PE); and PE systems comprising the PEs and one or more polymerase editing guide RNAs (PEgRNAs) (or polynucleotide(s) encoding the same). Vectors and host cells comprising the polynucleotides are also provided.