Fuente: WIPO "tomato" Described herein are systems, methods, and interconnecting porous hydrogel blocks for generating mammalian tissue. A block may comprise a three-dimensional continuous polymeric matrix with a network of microporous cavities, and may be configured to interconnect with at least one other block. A system may comprise a plurality of blocks configured to interconnect to form a scaffold configured to cultivate one or more cell types organized into stratified layers. A method may comprise acquiring a plurality of blocks, interconnecting the blocks to form a scaffold configured to cultivate one or more cell types organized into stratified layers, and seeding at least one block with at least one cell type adherent to the block. Embodiments may comprise perfusing at least one block with culture media and/or harvesting mammalian tissue generated.