Fuente: WIPO "tomato" Disclosed is an ionizable lipid comprising alkyl substituted 1, 4, 7-triazacyclononane or 1, 4, 7, 10-tetraazacyclododecane. Also disclosed is a lipid nanoparticle for delivering a nucleic acid, comprising the ionizable lipid as disclosed herein. Also disclosed is a nucleic acid-lipid nanoparticle comprising a nucleic acid and the lipid nanoparticle as disclosed herein. Further disclosed are pharmaceutical compositions and immunogenic compositions of the nanoparticles. Further disclosed are a method of treating a subject having a disease caused by deficiency in a functional peptide or protein and a method for vaccinating a subject, comprising administering to the subject the nucleic acid-lipid nanoparticle as disclosed herein.