Fuente: WIPO "tomato" Described herein are systems, methods, and interconnecting porous hydrogel blocks for generating personalized microvasculature ex vivo. A block may be configured to, under dynamic conditions, cultivate microvascular formation when seeded with at least one line of endothelial cells isolated from at least one first specimen and at least one line of mesenchymal stem cells isolated from at least one second specimen. A system may comprise at least one block so configured. A method may comprise seeding at least one block with at least one line of endothelial cells isolated from at least one first specimen and at least one line of mesenchymal stem cells isolated from at least one second specimen and exposing the cell types to dynamic culture conditions.