Fuente: WIPO "tomato" Provided herein are engineered epigenetic effectors, such as DNA methyltransferases and methylcytosine dioxygenases that are smaller than their naturally occurring counterparts. The engineered epigenetic effectors find use in regulating expression level of target genes in a cell, e.g., when targeted to a genetic locus of interest by a targeting moiety, such as a Cas protein, coupled thereto.