Fuente: WIPO "tomato" It has been established that the efficacy of mRNA vaccines encoding one or more peptide antigens for expression in a host cell can be enhanced by the addition of one or more mRNA sequences encoding peptide adjuvant(s) for expression of the adjuvant in the same host cell. Compositions of vaccines including mRNA sequences encoding peptide antigen(s) and peptide adjuvant(s) are described. The peptide antigen(s) and peptide adjuvant(s) can be encoded on the same or different mRNA molecule. In some forms, the vaccines include a single mRNA molecule encoding an antigen and an adjuvant, for expression in the same host cell. Nanoparticles encapsulating the mRNA sequences encoding peptide antigen(s) and peptide adjuvant(s) are provided for administration to a subject in vivo. Methods of vaccinating a subject including administering to the subject a composition including mRNA sequences encoding peptide antigen(s) and peptide adjuvant(s) are also described.