Fuente: WIPO "tomato" The present invention is related to a synergistic bioactive composition comprising flavonoids and a mixture of long-chain alcohols for controlling platelet hyperactivity and associated thrombotic risk. The composition comprises the combination of anthocyanin(s) and policosanol. The combination of anthocyanin(s) and policosanol effectively regulates platelet hyperactivity. The composition of present invention offers a promising solution for neuro-cardiovascular and metabolic health by harnessing the synergistic effects of anthocyanin(s) and policosanol. Further, the invention provides synergistic action in controlling platelet hyperactivity associated with diseases like stroke, diabetes, atherosclerosis, dyslipidemia, stent thrombosis.