Fecha de publicación: 21/11/2024 Fuente: PubMed "Cannabis" Am J Perinatol. 2024 Nov 21. doi: 10.1055/a-2480-3163. Online ahead of print.ABSTRACTTITLE: Impact of Cannabis Legalization on Umbilical Cord Tissue Tetrahydrocannabinol (THC) levels Objective: To assess the impact of cannabis legalization on both qualitative and quantitative umbilical cord tissue tetrahydrocannabinol (THC) rates and concentrations as a proxy for fetal exposure.STUDY DESIGN: This is a retrospective, observational study of umbilical cord tissue THC levels in a single center, comparing THC exposure rates and concentration levels before and after cannabis legalization in the state of Illinois, Epoch 1 (October 1,2018-June 30, 2019, pre-legalization) and Epoch 2 (July 1, 2019-August 31, 2021, post-legalization).RESULTS: 811 umbilical cords were analyzed during epoch 1 and 2170 during epoch 2. A higher percent of umbilical cord tissue tested positive for THC in Epoch 2 compared to Epoch 1 (46.2% vs. 40.6%; p<0.01). Mean THC levels were 51% higher in umbilical cord tissue in Epoch 2 vs. Epoch 1 (6.2ng/gm vs 4.1 ng/gm; p<0.001).CONCLUSIONS: Legalization of recreational cannabis was associated with more fetuses exposed to THC and in higher concentrations.PMID:39572239 | DOI:10.1055/a-2480-3163