Fecha de publicación: 09/09/2022 Fuente: WIPO "hemp" The invention provides a weight-losing composition and a preparation method, application and a preparation thereof, and belongs to the technical field of weight-losing preparations, the weight-losing composition comprises the following raw materials by weight: 2-6 parts of ginger, 3-6 parts of hawthorn, 2-7 parts of cassia seed, 3-5 parts of radish seed, 2-4 parts of lotus leaf, 3-6 parts of hemp seed, 2-4 parts of perilla fruit, 0.5-2 parts of calcium gluconate, 0.5-3 parts of konjaku flour, and 0.5-3 parts of inulin. The weight-losing composition reduces fat absorption by inhibiting primary adipocyte induced differentiation and/or adipocyte proliferation, and has the advantages of excellent weight-losing effect, high safety and no toxic or side effect. According to the preparation method disclosed by the invention, the paste yield of the weight-losing composition and the content of effective components such as total flavonoids and polysaccharides are remarkably improved, so that the weight-losing composition achieves the purpose of losing weight and reducing fat. The weight-losing preparation has the characteristics of safety, stability, quick absorption and quick effect.