Systems and methods for solvent-free direct extraction of target compounds from compositions of matter are disclosed herein. The disclosed systems and methods use low pressure to reduce the evaporation temperature of target compounds without affecting the chemical integrity thereof. Target compounds are extracted from the composition of matter in an evacuation chamber and then collected using a capture system. Target compounds may be drawn from the evacuation chamber into the capture system using a carrier gas to facilitate transport of the targeted compounds in the vapor phase. A processed vapor stream may be transported from the capture system back into the evacuation chamber using a recirculation system that includes a blower. The disclosed systems and methods may be used, for example, to extract target compounds from plant matter such as fresh or dried cannabis and hemp, lavender, rosemary, lilac, or other suitable plant matter containing desirable compounds for extraction.