Grafted cannabis plants and related methods for producing a grafted cannabis plant are provided. In some embodiments, a scion is provided from a first cannabis plant having at least one of a first desired phenotype and a first desired genotype and a rootstock is provided from a second cannabis plant having at least one of a second desired phenotype and a second desired genotype, the rootstock compatible with the scion. The scion may be grafted onto the rootstock to form the grafted plant. In some embodiments, the scion is from a drug-type cannabis plant and the rootstock is from a hemp plant. The grafted cannabis plant may have at least one enhanced plant trait, enhanced harvest trait, and/or emergent property. Related cannabis plant materials and cannabis-derived products are also provided.