Fecha de publicación: 05/01/2023 Fuente: WIPO Rice Disclosed are C16 ester derivatives of C2′epi-amphotericin B (C2′epiAmB) characterized by improved clinical efficacy with reduced toxicity compared to AmB. Also disclosed are pharmaceutical compositions comprising the C16 ester derivatives of C2′epiAmB, therapeutic methods of using the C16 ester derivatives of C2′epiAmB, and methods of making the C16 ester derivatives of C2′epiAmB.