Fecha de publicación: 05/01/2023 Fuente: WIPO Rice The present disclosure relates to compositions and methods that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within a plant genome. The disclosure provides base editing fusion polypeptides of a DNA binding domain, e.g., Cas9, and a cytidine deaminase domain. The base editors perform equally well or outperform existing technologies in C-to-T base editing efficiency while maintaining low frequency of introducing C-to-A and C-to-G byproducts.