Fuente: Broccoli Byproducts Extraction Diabetic neuropathy is a complication associated with diabetes mellitus caused by prolonged exposure to stress including hyperglycemia, inflammation, and nerve injury. This particularly involves chronic inflammation of the peripheral nerves that leads to damage of various structures of the peripheral nervous system (satellite cells, ganglia and nerve trunks). This relationship leads us to the importance of functional foods as a preventive and therapeutic tool in diabetic neuropathy. This chapter investigates the means through which functional foods reverse the actions of oxidative stress, inflammation, and mitochondrial dysfunction, which are some of the risk factors to diabetic neuropathy. It discusses the potential therapeutic effect of curcumin, omega-3 containing foods, probiotics and flavonoids, gumma extracted from green tea, black tea or dark chocolate on maintenance of nervous system integrity and regulation of blood glucose levels. Regards to clinical effectiveness of functional foods against neuropathy, bioavailability and variability of food composition as well as possible drug-food interactions in the background of diabetes have also been addressed. The chapter closes with remarks on the futures of functional foods, individual dieting and their role in diabetic management.