Fuente: Citrus Byproducts Extraction The rapid surge in wastewater pollution caused by global trade and human activities poses escalating challenges for agriculturists and scientists. Chemical flocculants, the conventional method of treating wastewater, are limited by their performance due to their nonbiodegradability and health risks, thereby necessitating the exploration of eco-friendly alternatives. Growing global awareness of environmental sustainability and the demand for eco-conscious wastewater treatment solutions have prompted a shift toward investigating plant-derived bioflocculants as a promising substitute for traditional approaches. This innovative endeavor includes the development of an environmentally safe filtration plant using natural and secondary raw materials. Through a comprehensive methodology incorporating modern theoretical and experimental techniques, pollutant concentrations are assessed, and a laboratory installation is constructed. Fallen leaves of trees like oak and poplar are often employed as part of the filtration process. Additionally, mathematical modelling techniques are employed to predict the distribution of treated effluent in ponds, offering valuable insights into residual pollutant concentrations during natural movement downstream. The multifaceted practical implications of these methodologies encompass the potential for effective biological purification of wastewater, alongside showcasing promising results in reducing heavy metals, dyes, organic compounds, suspended solids, and nitrates. As the global population burgeons exponentially, understanding and launching the concept of a green chemistry perspective for environmental safety becomes the need of the hour. This chapter discusses the application of plant-derived bioflocculants in wastewater treatment through a green chemistry approach, focusing on their potential to provide a safe and sustainable solution for environmental protection.