Fuente: Citrus Byproducts Extraction This chapter addresses sustainable and green strategies towards nanomaterials in the realm of health with a particular focus on synthesis, applications, and the environment. Green synthesis exhibits 90% antimicrobial activity, 70% diminishment of toxic by-products, and 80% improvement of therapeutic efficacy in targeted drug delivery of medicines, and biopolymeric nanocarriers improve drug stability by 80%. The study examines recent developments in green nanotechnology by critically examining the synthesis route, performance characteristics, and environmental evaluation. Synthesis includes pH-sensitive systems with encapsulation efficiency of 74.48%, temperature-sensitive systems with 95% total release when subjected to UV irritation, and intelligent nanomaterials with natural polymers like chitosan and cellulose employed in enhancing biocompatibility. Applications are drug delivery, cancer treatment, wound healing, and tissue engineering with a 60% recovery rate without bacterial resistance using bioceramics. Environmental analysis indicates 30% energy, 40% cost saving, and 50% increase in production relative to traditional methods. Life cycle assessment gives 63.7 kg CO2 equivalent emissions per kilogram of nanocellulose. The strategy involves comparative evaluation of green synthesis routes in comparison to traditional routes, antimicrobial activity, bioavailability, and toxicity profile evaluation. In response to regulatory standardization and scale-up production issues, the study targets solution through action by multidisciplinary teams. The findings form a basis for clinically active nanomaterials development with environmental sustainability.