Fuente: Textiles (MDPI) Textiles, Vol. 5, Pages 46: Innovative Wound Healing Utilizing Bioactive Fabrics Functionalized with Tormentillae rhizoma Extract: An In Vivo Study on Wistar Albino Rats
Textiles doi: 10.3390/textiles5040046
Authors:
Aleksandra Ivanovska
Jovana Bradić
Uroš Gašić
Filip Nikolić
Katarina Mihajlovski
Vladimir Jakovljević
Anica Petrović

This paper presents an innovative protocol for fabric functionalization using Tormentillae rhizoma extract, the chemical composition of which was proved via LC/MS analysis. The extract demonstrated antioxidant activity > 99%, and antibacterial efficacy against E. coli and S. aureus > 99%. Cotton, wool, polyamide, and cellulose acetate were functionalized with the prepared extract, all showing > 90% antioxidant activity. Functionalized cotton, wool, and polyamide exhibited > 99% antibacterial activity against both bacteria. Based on these findings and the fabrics’ ability to release bioactive compounds, functionalized cotton and polyamide fabrics having excellent bioactivity but a lower ability to release bioactive compounds can serve as protective fabrics for people with sensitive skin prone to wounds, and various products for hospitals. Functionalized wool was identified as the most suitable wound dressing for in vivo preclinical investigation on Wistar albino rats. The obtained results showcased a wound-healing rate of 95.54%, and hydroxyproline content of 8.08 µg/mg dry tissue for rats treated with functionalized wool. Compared to negative, positive, and a group of rats treated with non-functionalized wool, those treated with functionalized wool demonstrated elevated values of tissue redox state parameters, superoxide dismutase (SOD) and catalase (CAT), and a notable reduction in thiobarbituric acid reactive substances (TBARS) value. Analysis of the blood samples of rats treated with functionalized wool indicated increased levels of antioxidant defense system parameters (SOD and CAT) and decreased pro-oxidative markers superoxide (O2−) and TBARS. Further clinical trials are needed to validate these findings.