Fuente: Microorganisms - Revista científica (MDPI) Microorganisms, Vol. 13, Pages 2861: Comparative Mechanisms of Different Bifidobacteria in Combating Pathogen Infection and Prolonging the Lifespan in Caenorhabditis elegans
Microorganisms doi: 10.3390/microorganisms13122861
Authors:
Xueer Wang
Shixiang Wu
Wen Zhao
Zhaozhong Zeng
Jian He
Hanglian Lan
Bing Fang
Haina Gao
Yue Liu
Jingyu Li
Weilian Hung
Ming Zhang

The research employed Caenorhabditis elegans to compare the anti-infection and lifespan-extending properties of Bifidobacterium. The results demonstrated that BL-99 and YLGB-1496 intervention improved the nematodes’ resistance to Staphylococcus aureus infection, resulting in lifespan extensions of 5.90% and 14.38%, respectively, accompanied by the alleviation in the decline of pharyngeal pumping rate and locomotor capacity. Furthermore, both probiotic strains significantly extended the mean lifespan of nematodes by 10.96% and 12.14%, and significantly alleviated pharyngeal pumping and locomotion. Importantly, BL-99 and YLGB-1496 have different underlying mechanisms of action. Transcriptomic analyses indicated that the BL-99 strain enhanced nematode resistance to Gram-positive pathogens through the upregulation of lysozyme, saposin-like antimicrobial peptides, and c-type lectin family genes. Conversely, YLGB-1496 improved the epidermal permeability barrier by upregulating genes involved in collagen synthesis and assembly. Overall, this study provides novel insights into the species-specific effects of Bifidobacteria on pathogen resistance and lifespan extension.