Fuente: Molecules - Revista científica (MDPI) Molecules, Vol. 30, Pages 4788: Bromo Analogues of Active 3,4,5,4′-Tetramethoxy-trans-stilbene (DMU-212)—A New Path of Research to Anticancer Agents
Molecules doi: 10.3390/molecules30244788
Authors:
Dawid Łażewski
Gabriela Korzańska
Łukasz Popenda
Karolina Chmaj-Wierzchowska
Artur Korzański
Eduard Potapskyi
Julian Myszkiewicz
Agnieszka Gielara-Korzańska
Agnieszka Zgoła-Grześkowiak
Nataliya Finiuk
Yuliia Kozak
Iryna Ivasechko
Roman Lesyk
Joanna Kuźmińska
Tomasz Goslinski
Marcin Wierzchowski

Stilbenes are a group of polyphenols that are gaining steady attention and have promising biological activity. While much attention is given to polyhydroxy compounds derived from resveratrol, other substituents remain largely unexplored. In this work, we present the results of studies on the synthesis, physicochemical characterisation, and ADME parameters simulation of polymethoxy and brominated stilbenes. We also examined their anticancer activity and found that some of the brominated compounds reveal desirable properties. While the brominated derivatives are not significantly more active than the polymethoxy derivatives, they were found to be safer for the tested pseudo-normal cell lines.