Fecha de publicación: 29/10/2024 Fuente: Molecules - Revista científica (MDPI) Molecules, Vol. 29, Pages 5098: Fabrication of Rapidly Soluble Zn2+-Releasing Phosphate-Based Glass and Its Incorporation into Dental Resin
Molecules doi: 10.3390/molecules29215098
Authors:
Fan Deng
Haruaki Kitagawa
Tomoki Kohno
Tingyi Wu
Naoya Funayama
Pasiree Thongthai
Hefei Li
Gabriela L. Abe
Ranna Kitagawa
Jun-Ichi Sasaki
Satoshi Imazato

Phosphate-based glasses are known for their excellent biocompatibility and adjustable degradation rates. In this study, we fabricated a rapidly soluble zinc-ion-releasing phosphate-based glass (RG) specifically designed for use in dental cavity liners. The aim of this study was to evaluate the ion-releasing properties and antibacterial effects of RG. Additionally, a dental resin incorporating RG was fabricated to serve as a cavity liner, and its effectiveness was investigated in vitro. The RG formulation exhibited high solubility and released high concentrations of Zn2+ at various pH values. To assess the antibacterial properties of RG, six bacterial species detected in deep carious regions were incubated in the presence of RG. In vitro antibacterial testing against six bacterial species revealed that RG exhibited strong bactericidal effects against these prevalent bacteria. Furthermore, using a dentin model infected with Lactobacillus casei or Streptococcus mutans, the experimental resin containing RG demonstrated an effective bactericidal effect in the dentinal tubules, highlighting its potential as a promising material for cavity liners or pulp-capping applications.