Fecha de publicación: 21/10/2024 Fuente: Journal of applied polymer Lugar: RESEARCH ARTICLE In this study, nanoelectrospinning technology was used to prepare a Janus nanofiber mask loaded with Gastrodia elata polysaccharide, and the spinning conditions of PLA/PVP/MT nanofiber film and CS/GEL/GEP nanofiber film were discussed. According to the optimized spinning conditions, Janus nanofiber film was prepared by double-needle spinning and layer-by-layer electrospinning. Then, the apparent morphology, infrared spectrum, mechanical properties, thermal stability, water contact Angle, water vapor transmittance, antioxidant and antibacterial activity of the nanofiber membrane before and after drug loading were characterized, and the Janus nanofiber membrane with good morphology, excellent tensile ability, effective free radical scavenging and good antibacterial performance was obtained. The efficacy of the prepared nanofiber mask was further evaluated, and the nanofiber mask with safe, non-stimulating and good moisturizing properties was obtained, which is expected to be applied in the field of skin care products as a new type of mask.


Abstract
Facial masks available in the market are primarily made of non-woven fabric. To extend their shelf life, preservatives, and essences are added to their ingredients. However, this practice has a significant impact on the environment and human health. As a result, consumers nowadays prefer to choose “Clean Beauty” products for their skincare routines. Herein, electrospinning technology was used to prepare a novel Janus nanofiber membrane comprising Polylactic acid/Polyvinylpyrrolidone (PLA/PVP) and Chitosan/Gelatin (CS/GEL), loaded with Gastrodia elata polysaccharide (GEP) and melatonin (MT). The Janus nanofiber facial mask is a solid mask that provides excellent moisturizing, antioxidant, and biocompatibility benefits. It can dissolve quickly and be absorbed by the skin, while the hydrophobic fiber helps slow down the rapid evaporation of water in the mask. This, combined with the Janus structure, helps delay the loss of water and allows for quick penetration, resulting in a long-lasting moisturizing effect. Therefore, the Janus nanofiber facial mask is an ideal choice for solid facial masks and provides technical support for its application in this field.