Fuente: Journal of applied polymer Lugar: RESEARCH ARTICLE Preparation and Application Schematic Diagram of GO-Embedded PVP Electrospun Fibers with Near-Infrared Response.

ABSTRACT
Effective hemostasis and pathogenic microorganism clearance are essential primary steps for establishing a stable internal microenvironment during the early stage of wound repair. Therefore, a simultaneous thermal crosslinking-integration strategy was applied to electrospun polyvinylpyrrolidone (PVP) and graphene oxide nanosheets (GO) composite fibers to achieve early-stage intervention for acute wounds. During thermal crosslinking, molecular thermal motion facilitates interactions between PVP and GO via various non-covalent interactions, thereby further stabilizing the macromolecular chains. Specifically, the fabricated PVP-G5 membranes exhibit robust morphological stability in aqueous environments, enabling them to accommodate excessive wound exudate. As a supporting substrate, the fibrous structure of PVP-G5 also facilitates platelet accumulation, thereby providing a favorable physical platform for activating the blood coagulation cascade. Furthermore, the embedded GO nanosheets within the fiber matrix not only ensure biocompatibility but also endow the fibrous membranes with NIR-switched photothermal therapy (PTT), thus achieving broad-spectrum pathogen eradication. These findings demonstrate that the PVP-GO composite fiber membranes, fabricated through the in situ thermal integration strategy during crosslinking, offer significant advantages for managing severe bleeding and infection, with promise for early treatment of acute wounds.