Fecha de publicación: 23/12/2024 Fuente: Polymers Polymers, Vol. 16, Pages 3614: 3D-Printed Acrylated Soybean Oil Scaffolds with Vitrimeric Properties Reinforced by Tellurium-Doped Bioactive Glass
Polymers doi: 10.3390/polym16243614
Authors:
Matteo Bergoglio
Matthias Kriehuber
Bernhard Sölle
Elisabeth Rossegger
Sandra Schlögl
Ziba Najmi
Andrea Cochis
Federica Ferla
Marta Miola
Enrica Vernè
Marco Sangermano

In this study, we present novel, vitrimeric and biobased scaffolds that are designed for hard tissue applications, composed of acrylated, epoxidized soybean oil (AESO) and reinforced with bioactive glass that is Tellurium doped (BG-Te) and BG-Te silanized, to tune the mechanical and antibacterial properties. The manufacture’s method consisted of a DLP 3D-printing method, enabling precise resolution and the possibility to manufacture a hollow and complex structure. The resin formulation was optimized with a biobased, reactive diluent to adjust the viscosity for an optimal 3D-printing process. The in vitro biological evaluation of the 3D-printed scaffolds, combined with BG-Te and BG-Te-Sil, showed that the sample’s surfaces remained safe for hBMSCs’ attachment and proliferation. The number of S. aureus that adhered to the BG-Te was 87% and 54% lower than on the pristine (control) and BG-Te-Sil, respectively, with the eradication of microbiofilm aggregates. This work highlights the effect of the vitrimeric polymer matrix and doped, bioactive glass in manufacturing biocompatible, biobased, and antibacterial scaffold used in hard tissue application.