Fecha de publicación: 28/10/2024 Fuente: Polymers Polymers, Vol. 16, Pages 3022: Sources and Methods for the Production of Xyloglucan, a Promising Stimulus-Sensitive Biopolymer: A Review
Polymers doi: 10.3390/polym16213022
Authors:
Elena O. Bakhrushina
Victor S. Pyzhov
Jana A. Yuntunen
Alexander S. Gulenkov
Shoyad D. Arislanov
Ksenia V. Eremeeva
Anastasiya V. Belyatskaya
Natalia B. Demina
Ivan I. Krasnyuk
Ivan I. Krasnyuk

Xyloglucan is a highly promising ‘green’ polymer that has found its application in the food and pharmaceutical industries. Due to its molecular structure similarity to mucin, it has remarkable mucoadhesion properties, which has led to a high research interest in this excipient for the development of transmucosal delivery systems. Thermosensitivity is another promising property of xyloglucan derivatives, which is mainly exhibited by synthetic block copolymers such as pluronics and PLGA derivatives. Delivery systems whose mechanism of active ingredient release is based on temperature sensitivity are widely used in many medical fields, ranging from antitumour therapy to intranasal delivery. Thus, conducting research on the possibility of obtaining and using a new mucoadhesive, fully biocompatible and affordable polymer—xyloglucan—is a promising task.