Fecha de publicación: 10/01/2025 Fuente: Molecules - Revista científica (MDPI) Molecules, Vol. 30, Pages 250: Iron-Catalyzed Cross-Dehydrogenative Coupling
Molecules doi: 10.3390/molecules30020250
Authors:
Haiyan Diao
Yujia Chen
Feng Liu

This review highlights significant advances in iron-catalyzed cross-dehydrogenative coupling (CDC), a method pivotal for forming carbon-carbon (C-C) bonds directly from C-H bonds. This technique uses iron—a naturally abundant, inexpensive, and environmentally benign transition metal—as a catalyst to facilitate the coupling of two unfunctionalized C-H bonds. This method stands out for avoiding pre-functionalized substrates, reducing both waste and cost in organic synthesis. The discussion includes a variety of CDC methodologies involving combinations of C(sp3)-H with C(sp3)-H, C(sp3)-H with C(sp2)-H, and C(sp3)-H with C(sp)-H bonds. These methods have been successfully applied in synthesizing complex molecules and pharmaceuticals, highlighting the versatility and efficiency of iron catalysis.