Fuente: Wipo "Sensorization" Ambulatory medical devices that provide therapy to a subject, such as blood glucose control, are disclosed. Disclosed systems and devices can implement one or more features that improve the user experience, such as maintain delivery of therapy to a subject after determining that a possible occlusion exists in a medicament delivery system. The system can receive an indication of an amount of initial medicament in possession of the subject and determine a rate of consumption of medicament. The system can determine the amount of total remaining medicament and determine that the amount of the total remaining medicament is below a threshold amount. Based on this, the system may generate a user alert that indicates that additional supply of medicament may be necessary.