Fuente: Wipo "digitalization" Systems and methods for optimizing a digital message campaign response are provided where a relationship is discovered between (i) variance in the absence or presence of one or more elements in digital message across a first plurality of digital messages for a first plurality of recipients and (ii) variance in performance of at least one selected response event across the first plurality of recipients. The relationship is used to modify or create a campaign rule that specifies a frequency or range of frequencies for incorporation of an element in digital messages. The campaign rule is used as a basis for determining a frequency of incorporation of an element in a second plurality of digital messages sent to a second plurality of recipients in the campaign. The relationship discovery and campaign rule modification or creation continues on an ongoing basis throughout the campaign and, optionally, after the campaign is completed.