Fuente: Journal of applied polymer Lugar: REVIEW Flexible electronic skin (e-skin) is advancing from health monitoring to personalized therapy, enabling targeted drug release, tissue repair and regeneration, dynamic therapy, and multi-therapy integration through innovative substrate materials and adaptive designs.


ABSTRACT
Flexible electronic skin (e-skin) holds significant promise in personal therapy by enabling customized therapeutic strategies such as targeted drug delivery, tissue regeneration, and adaptable treatment modalities. Unlike conventional medical devices, e-skin offers comfortability and continuous monitoring capabilities, making it particularly suitable for long-term therapeutic applications. However, the challenges such as mechanical flexibility, self-healing and biocompatibility remain critical for its reliable integration with the human body, especially under dynamic mechanical deformation and on irregular skin surfaces. Whereas previous reviews have mainly focused on fragmented aspects such as drug delivery, biosensing, or wound repair, this review takes a holistic perspective by evaluating e-skin from the overall standpoint of therapeutic efficacy. This review highlights how substrate materials for e-skin innovation enable the transition from simple health monitoring toward advanced therapeutic applications in personalized therapy. Key substrate materials explored include organic polymers, silicones, and hydrogels, each offering distinct mechanical properties and processing advantages. While extensive studies have addressed the applications of e-skin in biosensing and diagnostics, there is still a notable gap in systematically explore its role in integrated personalized therapeutics. This review aims to expand the existing research framework by providing a comprehensive analysis of the latest advancements in e-skin technology for customized therapies. Through this analysis, paving the way for future research directions and practical applications of e-skin in the landscape of personalized treatment, ultimately contributing to enhanced patient care and therapeutic outcomes.