Fecha de publicación: -- Fuente: PubMed "rice" Mol Plant Pathol. 2026 Nov;27(11):e70384. doi: 10.1111/mpp.70384.ABSTRACTPlant immunity depends on coordination between immune receptors and hormone-responsive transcriptional networks, yet how CBP60 proteins contribute to disease resistance in monocots remains poorly understood. Here, we characterized OsCBP609, a rice CBP60 family protein involved in resistance to Magnaporthe oryzae. Expression of OsCBP609 was responsive to M. oryzae infection and defence-related signals, and the encoded protein localized to the nucleus and exhibited transcriptional activation. CRISPR/Cas9-mediated disruption of OsCBP609 increased lesion development and fungal biomass following infection with multiple M. oryzae isolates. Transcriptome profiling showed that loss of OsCBP609 was associated with altered expression of genes involved in plant-pathogen interactions and hormone-related signalling pathways during infection. Although basal salicylic acid (SA) levels were elevated in the oscbp609 mutant, SA-responsive defence transcription was attenuated, and exogenous SA failed to restore resistance to the wild-type level, supporting a role for OsCBP609 in the transcriptional response to SA. OsCBP609 physically interacted with the NLR protein Pik1-H4 in the nucleus, and co-expression of the two proteins produced significantly higher reporter activity than expression of either protein alone. Disruption of OsCBP609 in a Pik-H4 near-isogenic line also reduced blast resistance, supporting a functional contribution of OsCBP609 to Pik-H4-associated immunity. Together, these results identify OsCBP609 as a CBP60 transcriptional regulator that supports SA-responsive defence and Pik-H4-associated resistance to rice blast.PMID:43000518 | DOI:10.1111/mpp.70384