Fecha de publicación: 05/01/2023 Fuente: WIPO Rice Topical skin compositions and methods for their use are disclosed. The compositions can include at least one skin active ingredient capable of treating a skin condition, and a plurality of skin penetration enhancers capable of increasing the penetration of the skin active into the skin. The plurality of skin penetration enhancers can include alcohol, dimethyl isosorbide, pentylene glycol, ethoxydiglycol, and propylene glycol.