Fecha de publicación: 05/01/2023 Fuente: WIPO Rice Aspects of the present disclosure relate generally to chimeric proteins and pharmaceutical compositions comprising such chimeric proteins, and methods for using such chimeric proteins for treating kidney diseases. Aspects of the disclosure relate to a chimeric protein comprising a targeting domain comprising a scFv having a binding specificity to a cell surface protein of a kidney tissue, and an activator domain comprising a growth factor.