Fuente: WIPO "apiculture" FIELD: apiculture technologies. SUBSTANCE: method relates to application of biological active materials in apiculture. According to method, carried out in autumn period is combined treatment of bee families by antivarroatose preparation called "Bipin" taken in the form of water solution of 6.25x10-3% concentration and containing ecdisteroid-ecdisteron in amount of 3-3x10-4 mg. Application amount is 10 ml per single bee headway. Combined treatment of bee families by "Bipin" preparation and ecdisteron ensures better survival and retention of force by bee families in hibernation period. EFFECT: higher efficiency. 2 tbl, 3 ex