Fuente: PubMed "bee pollen" Biomed Res Int. 2026 Jan 30;2026:3824359. doi: 10.1155/bmri/3824359. eCollection 2026.ABSTRACTINTRODUCTION: Bee pollen, a natural product rich in polyphenols, exhibits remarkable antioxidant, anti-inflammatory, and hepatoprotective properties.AIM: This study was aimed at evaluating the hepatoprotective effects of solid lipid nanoparticles (SLNs) loaded with bee pollen.MATERIALS AND METHODS: SLNs were formulated and optimized by varying surfactant ratios and lipid contents at two different temperatures.RESULTS AND DISCUSSION: The optimized bee pollen SLNs demonstrated a particle size of 118.6 nm, a PdI of 0.35, a zeta potential of -22.6 mV, and an entrapment efficiency of 92.7%. The in vitro release study showed minimal release during the initial 120 min, followed by a continuous increase up to 48 h, indicating a sustained and prolonged release profile. Both bee pollen and bee pollen ethanolic extract-loaded SLNs exhibited significant cytoprotective effects against lead-induced cytotoxicity in HepG2 cells. In vivo studies revealed that treatment with bee pollen and especially bee pollen SLNs substantially ameliorated lead-induced hepatic injury. Treatment notably reduced serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, malondialdehyde, and nitric oxide. Additionally, it enhanced the activity of glutathione peroxidase, catalase, superoxide dismutase, and total antioxidant capacity, as well as levels of total thiol, reduced glutathione, and liver tissue proteins. Histopathological analysis further confirmed that treatment, particularly with bee pollen SLNs, significantly improved lead-induced hepatic structural damage.CONCLUSION: These findings confirm that bee pollen, and more prominently its SLN formulation, possesses strong hepatoprotective potential.PMID:41623692 | PMC:PMC12856774 | DOI:10.1155/bmri/3824359