Fuente: PubMed "bee pollen" Food Chem. 2026 Feb 4;508(Pt A):148318. doi: 10.1016/j.foodchem.2026.148318. Online ahead of print.ABSTRACTBee-collected pollen (BCP) is a nearly complete food, but its hard wall limits the release of chemical compounds. We previously found that ultrasonication-assisted treatment of rape BCP with cellulase, pectinase, and Protamex™ protease (U-3ER) can effectively broke the pollen wall. However, the digestion of chemical compounds from wall-broken pollen remains unclear. This study evaluated the morphology, chemical composition, and anti-inflammatory effects of U-3ER. The results showed that the digested U-3ER was in the form of fragments with a particle size of 5.20 ± 0.65 μm. The bioaccessibility of phenolics and flavonoids reached 118.0% and 136.4%, respectively. Furthermore, 200 μg/mL of digested U-3ER significantly inhibited NO production and reduced TNF-α and IL-1β secretion, thus alleviating the inflammatory response. In conclusion, simulated digestion enhances the bioaccessibility of chemical compounds in U-3ER. These findings provide an important foundation for developing high-value-added pollen products.PMID:41666578 | DOI:10.1016/j.foodchem.2026.148318