Preparation method of a colloidal system of stabilisation and controlled release of royal jelly ingredients, wherein the said system is characterized by the extraction of the components of the royal jelly and the simultaneous encapsulation in combinatorial liposome - cyclodextrin carriers for achieving controlled release, taking advantage of the special features of both carriers, namely: the ability of cyclodextrins to encapsulate polyphenols and their enhanced skin penetration ability as well as the ability of liposomes in encapsulating large amounts of components of various degrees of polarity, for local component transport and for controlled release rate.