PROBLEM TO BE SOLVED: To provide a neuromodulator which can exhibit an excellent neuromolating action, to provide a method for producing the neuromodulator, by which the neuromodulator can easily be produced from royal jelly, and to provide a neuromodulation composition, a food preparation and a cosmetic preparation which each can exhibit an excellent neuromolating action.SOLUTION: The neuromodulator, the food preparation and the cosmetic preparation each contains at least one of 1-N-hydroxyadenosine and 1-N-hydroxyadenosine-5'-phosphate as an active ingredient. This method for producing the neuromodulator comprises mixing royal jelly with a buffer solution, adding the extract to a separation carrier or resin such as a molecular sieve carrier, and then collecting the neuromodulator with a separation solvent such as a buffer solution. The neuromodulation composition contains the neuromodulator and neurotrophin.COPYRIGHT: (C)2004,JPO