The invention relates to processing methods to produce Bee Product Extracts produced from a Bee Product such as honey, pollen, waxes, or royal jelly; and in particular a Bee Product Extract produced from purifying manuka honey with cation-exchange; their uses, methods of preparation and methods of their detection and analysis. The Bee Product Extract of the invention contains phenolics, minerals and proteins coordinated in a complex that undergoes photo-Fenton chemistry process to generate high energy short lived radicals, including Hydroxyl radicals and superoxide radicals. The formulated Bee Product Extract can provide a topical form to be used as a spray, mist or serum for the treatment of a wide range of human and animal diseases and to maintain health and well-being.