A composition for the treatment of otitis in a mammal includes therapeutically anti-otitis effective amounts of propolis compounds in a pharmaceutically acceptable carrier, along with an antimicrobial metal-containing nanoparticles selected from the group consisting of silver, gold, aluminum, copper and zinc; and curcumin in a pharmaceutically acceptable carrier. In addition, the invention is directed to a method of treating an animal suspected of suffering from otitis comprising administering to an ear of the animal a composition as described above.