The present invention relates to an apparatus for manufacturing powder of propolis byproducts, which comprises a vacuum dryer for drying in a vacuum state after loading propolis byproducts on a tray and inputting the tray in a vacuum dryer; a blender for mixing after adding a solid powder of lactose or glucose, dextrin, corn starch, etc. to the vacuum dried propolis byproducts; and a pulverizer having a cooler so that the propolis byproducts uniformly mixed with solid powder do not agglomerate due to temperature rise in the process of being pulverized into a particulate state. COPYRIGHT KIPO 2014