Fecha de publicación: 10/11/2022 Fuente: WIPO "apis cerana" The disclosure provides compositions and methods for treating and vaccinating insects and insect populations from bacterial diseases. The disclosure further provides compositions and methods for prophylactically immunizing honeybee hive to protect from infection with Foulbrood disease. In embodiments, the disclosure further provides compositions and methods for prophylactically immunizing honeybee hive to protect from infection with American foulbrood caused by Paenibaccilus larvae.