Systems and methods for use in facilitating application interface (API) interactions are disclosed. One exemplary method includes receiving, by a computing device, a primary API request from a client. The primary API request includes a plurality of parameters in association with a plurality of values. The computing device identifies relationships between the parameters and a plurality of interfaces, and generates a plurality of secondary requests based on the primary API request and the identified relationships. The computing device further transmits each of the plurality of secondary requests to the plurality of interfaces and receives a plurality of secondary responses from the plurality of interfaces. The computing device then generates a primary response based on the secondary responses and transmits the primary response to the client.