Fecha de publicación: 24/05/2007 Fuente: WIPO "miel" The invention provides a method for determining the risk of a human developing major depressive disorder (MDD) or a related disorder and method of diagnosing MDD or a related disorder in a human. Both methods comprise screening a human sample for the presence of a DNA sequence variation in the promoter of a CREB1 gene. The invention also provides methods of identifying a drug that treats MDD or a related disorder, a transgenic animal comprising a CREB1 gene operatively linked to a variant CREB1 promoter, an isolated or purified nucleic acid sequence comprising a variant CREB1 promoter operably linked to a reporter gene, and an isolated cell and cell line comprising a gene operatively linked to a variant CREB1 promoter.