Fecha de publicación: 09/11/2018 Fuente: WIPO "miel" The present invention relates to a coupling assembly in which an immunoglobulin Fc region is coupled to therapeutic enzymes through a non-peptide polymer connecting part, and relates to: a coupling assembly in which a non-peptide polymer connecting part is specifically coupled to an immunoglobulin Fc; a production method therefor; and a composition containing the same.