Fuente: PubMed "apiculture" iScience. 2026 Feb 9;29(3):114947. doi: 10.1016/j.isci.2026.114947. eCollection 2026 Mar 20.ABSTRACTGlycolysis plays a crucial role in neuronal homeostasis and is regulated by neuroendocrine signals, particularly dopamine, yet the underlying mechanisms remain unclear. Metabolomics showed that bromocriptine (BRC), a dopamine receptor agonist, increased glycolytic flux in forager bees, as indicated by higher glucose levels, accumulation of glycolytic intermediates, and reduced pentose-phosphate pathway metabolites. Single-cell and single-nucleus RNA-seq further indicated that acetylcholine (ACh) released by Kenyon cells may mediate dopamine-regulated glycolysis in surface glia (SG). We also observed coordinated insulin/insulin-like growth factor signaling (IIS) between cortex glia (CG) and SG. Mechanistically, co-administration of a nicotinic ACh receptor agonist with BRC attenuated the BRC-induced upregulation of SLC2A1, HK, and IGF transcripts, consistent with the proposed pathway. Together, these findings are consistent with a dual regulatory scheme in which a dopamine-ACh axis operates in concert with IIS to shape glial metabolic plasticity with cell-type specificity.PMID:41797926 | PMC:PMC12964235 | DOI:10.1016/j.isci.2026.114947