Fuente: PubMed "royal jelly" Food Res Int. 2025 Dec;221(Pt 4):117495. doi: 10.1016/j.foodres.2025.117495. Epub 2025 Sep 16.ABSTRACTPolyphenols extracted from Ascophyllum nodosum (PEAn) exhibit significant bioactivities but are limited by poor photothermal stability and low membrane permeability, which hinder their applications. This study explores the use of royal jelly exosomes (RExo) as a novel food-derived nanocarrier to enhance the stability and targeted delivery of PEAn. RExo (105.01 ± 7.24 nm) demonstrated a spherical morphology and expressed key exosomal markers (CD63, CD81, TSG101), enriched in metabolism-related proteins. The yield of RExo was optimized to a 12.72-fold increase at pH 6.0 compared to pH 2.0. Ultrasound-assisted loading achieved 85.73 ± 1.73 % encapsulation efficiency, as confirmed by spectroscopic analysis. Encapsulation significantly enhanced the photothermal stability and gastrointestinal tolerance of PEAn. In B16F10 cells, RExo improved PEAn uptake, inhibited tyrosinase activity, reduced melanin synthesis, and suppressed cell migration. Mechanistically, the anti-melanogenic effect of PEAn-RExo may be partially dependent on autophagy induction. This study provides a promising natural strategy for the development of functional foods and personalized nutrient delivery systems.PMID:41185370 | DOI:10.1016/j.foodres.2025.117495