Fuente: PubMed "royal jelly" Food Chem. 2026 Mar 1;504:147864. doi: 10.1016/j.foodchem.2026.147864. Epub 2026 Jan 6.ABSTRACTInterest in the safety of bee products such as honey, beeswax, bee bread, pollen, and royal jelly continues to grow. Although valued for their nutritional and therapeutic properties, these matrices may accumulate pesticides, antibiotics, PAHs, PCBs, and plasticizers from environmental and apicultural sources. Given their complex composition, reliable contaminant analysis requires efficient sample-preparation strategies. This review critically evaluates 50 studies published between 2018 and 2024 that applied standard or modified QuEChERS protocols to bee-derived matrices. Key trends include the predominant use of acidified acetonitrile, increasing reliance on advanced sorbents such as C18, Z-Sep, EMR-Lipid, and graphene, and a shift toward multi-residue LC-MS/MS and GC-MS/MS workflows offering high sensitivity across diverse analytes. Greenness assessment using AGREE revealed considerable methodological variability. Overall, the findings highlight both the versatility and limitations of modified QuEChERS methods and identify future needs, including greener extraction solutions and the analytical monitoring of emerging contaminants.PMID:41520637 | DOI:10.1016/j.foodchem.2026.147864