Fecha de publicación: -- Fuente: PubMed "propolis" Pathogens. 2026 Sep 15;15(9):980. doi: 10.3390/pathogens15090980.ABSTRACTPropolis has potential anthelmintic activity against Schistosoma mansoni, although its mechanisms remain poorly characterized. This study evaluated the biological effects of standardized Apis mellifera propolis extract (EPP-AF®) in experimental murine schistosomiasis. In vitro, EPP-AF® reduced adult worm viability and motility. In vivo, Swiss mice were allocated to four groups: EPP-AF® (4.5 mg/kg/day, orally, for 30 days), Praziquantel (PZQ; 50 mg/kg, days 45-51 post-infection), infected untreated control, and uninfected untreated SHAM control. EPP-AF® delayed oviposition and reduced egg production and tissue retention, granuloma formation, hepatic fibrosis, and eosinophilia. It also modulated splenic cytokine production, reducing inflammatory mediators and increasing IL-10. Molecular docking indicated favorable interactions between propolis phenolic compounds and SmCB1. Collectively, EPP-AF® exhibited antiparasitic and tissue-protective effects during experimental S. mansoni infection, supporting its pharmacological potential against schistosomiasis.PMID:42796748 | PMC:PMC13610971 | DOI:10.3390/pathogens15090980