Fuente: PubMed "propolis" Nat Prod Res. 2026 Apr 28:1-14. doi: 10.1080/14786419.2026.2662419. Online ahead of print.ABSTRACTIn this work, we evaluated the chemical composition and the potential of ethyl acetate fractions of propolis from Babor (EAFPB) and El-Menia (EAFPM) regions against human neuroblastoma SH-SY5Y. The inhibitory of MDM2-P53 interaction by propolis phytochemicals was also evaluated by molecular docking and molecular dynamics simulations. HPLC-DAD revealed the predominance of phenolic acids such as vanillic acid, p-coumaric acid, cynarin; and flavonoids such as naringenin, hesperetin and hesperidin. Besides, fumaric acid and esculetin were detected for the first time in Algerian propolis. In vitro studies validated the selective anticancer and apoptotic properties of propolis fractions, and confirmed the absence of genotoxic effects. Molecular docking and molecular dynamics revealed good binding affinities and stable interactions of Kaempferol, Naringenin, Hesperetin, Apigenin and Luteolin with MDM2. Overall, the findings highlight the potential of Algerian propolis-derived compounds as selective anticancer agents against neuroblastoma.PMID:42051013 | DOI:10.1080/14786419.2026.2662419