Fecha de publicación: -- Fuente: PubMed "propolis" Med Princ Pract. 2026 Sep 2:1. doi: 10.1159/mpp/adpag016. Online ahead of print.ABSTRACTOBJECTIVE: This study aimed to evaluate the remineralization potential and antibacterial activity of 5 commercially available pediatric toothpastes with different active ingredients.SUBJECT AND METHODS: The evaluated toothpastes were Kids Ozon, Oral-B Pro-Kids, Dentiste Junior Postbiotics, Curasept Biosmalto and Zubio. To assess remineralization efficacy, 48 specimens from extracted third molars were subjected to baseline microhardness testing. The samples were divided into six groups: five experimental and one negative control (n = 8). After 4 days in a demineralizing solution, microhardness was remeasured, followed by a 14-day pH-cycling protocol at 37 °C with twice-daily toothpaste applications. Final microhardness values were recorded and statistically analyzed. For antibacterial assessment, the agar diffusion method was applied using Streptococcus mutans, Lactobacillus acidophilus, Enterococcus faecalis and Candida albicans.RESULTS: All the tested toothpastes produced statistically significant remineralization of initial enamel carious lesions (p < 0.05). The microhardness ranking after pH-cycling was: Kids Ozon > Dentiste Junior Postbiotics > Curasept Biosmalto > Zubio > Oral-B Pro-Kids > negative control. However, intergroup differences weren't statistically significant (p > 0.05). All formulations showed antibacterial activity against the tested microorganisms. For S. mutans, Curasept Biosmalto had a significantly larger inhibition zone than Kids Ozon (p < 0.05). Although Curasept Biosmalto showed relatively higher antibacterial activity, differences among the other formulations were not significant (p > 0.05).CONCLUSION: Fluoridated and hydroxyapatite-based toothpastes exhibited comparable remineralization potential and antibacterial activity under in vitro conditions. The addition of other agents (ozone, propolis, and postbiotics) showed statistically non-significant improvements under the present experimental conditions.PMID:42684973 | DOI:10.1159/mpp/adpag016